Acquisition et analyse automatisées d'images à haute densité pour la découverte de médicaments et la biologie cellulaire
Le système d'imagerie à haute densité CELENA® X (HCI aussi appelé HCA) est un système d'imagerie intégré conçu pour l'acquisition et l'analyse rapides d'images à haut contenu. L'imagerie de plaques et la numérisation de lames sont facilitées par des protocoles d'imagerie personnalisables, un module d'autofocus laser oubien un autofocus basés sur l'image, ainsi qu'une platine motorisée en XYZ. Le logiciel intégré CELENA® X Cell Analyzer traite les images et les données pour une analyse quantitative. Dans le pipeline d'analyse, les objets cellulaires ou subcellulaires peuvent être identifiés, les images sont traitées pour une collecte optimale des données et diverses mesures supplémentaires peuvent être effectuées. Le CELENA® X est aussi flexible que puissant, avec des objectifs et des cubes à filtres interchangeables pour s'adapter à un large éventail d'applications d'imagerie de cellules fixes et vivantes.
Great to use, inexpensive - watch out big microscopy companies...
The Celena-X is so easy to use, it has huge flexibility and it is oh so affordable making the 'big name brands' look like a rip off!
ATA Scientific
Perfect combination of high content and high quality imaging.
The speed of image acquisition is outstanding and the images generated are of high quality. Together with the easy-to-use software, it is a great product.
Institut für Zellbiologie und Immunologie Stuttgart
Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.
2021. Shim MS, Nettesheim A, Dixon A, Liton PB. Proceedings of the National Academy of Sciences of the United States of America 118(13):e2021942118.
Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma.
2021. Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Journal of Clinical Medicine 10(1):78.
Indirubin-3'-monoxime induces paraptosis in MDA-MB-231 breast cancer cells by transmitting Ca 2+ from endoplasmic reticulum to mitochondria.
2021. Dilshara MG, Neelaka Molagoda IM, Prasad Tharanga Jayasooriya RG, Choi YH, Park C, Kim GY. Archives of Biochemistry and Biophysics 698:108723.
Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis.
2020. Park IS, Mahapatra C, Park JS, Dashnyam K, Kim JW, Ahn JC, Chung PS, Yoon DS, Mandakhbayar N, Singh RK, Lee JH, Leong KW, Kim HW. Biomaterials 242:119919.
Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention.
2020. Freidus LG, Kumar P, Marimuthu T, Pradeep P, Pillay V, Choonara YE. Molecules (Basel, Switzerland) 25(19):4471.
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| Cat # | Product | Qty |
|---|---|---|
| CX30000 | CELENA® X High Content Imaging System | 1 unit |
| I10530 | CX Stage Top Incubator, Basic [Tokai] | 1 set |
| I10531 | CX Stage Top Incubator, Pro [Tokai] | 1 set |
| I10500 | Heating System for Multi-well Plates [Ibidi] | 1 set |
| I10502 | Gas Incubation System for CO2 [Ibidi] | 1 set |
| I10503 | Gas Incubation System for CO2/O2 [Ibidi] | 1 set |
| I10030 | UPLFLN 4X, Olympus | 1 unit |
| I10031 | UPLFLN 10X2, Olympus | 1 unit |
| I10034 | LUCPLFLN 20X, Olympus | 1 unit |
| I10035 | LUCPLFLN 40X, Olympus | 1 unit |
| I10038 | UPLFLN 4XPH, Olympus | 1 unit |
| I10039 | UPLFLN 10X2PH, Olympus | 1 unit |
| I10042 | LUCPLFLN 20XPH, Olympus | 1 unit |
| I10043 | LUCPLFLN 40XPH, Olympus | 1 unit |
| I10046 | PLAPON 1.25X, Olympus | 1 unit |
| I10047 | PLAPON 2X, Olympus | 1 unit |
| I10052 | UPLXAPO 60XO, Olympus | 1 unit |
| I10051 | UPLXAPO 100XO, Olympus | 1 unit |
| I10130 | DAPI (Ex395/25, Em460/50) | 1 unit |
| I10131 | EGFP (Ex470/30, Em530/50) | 1 unit |
| I10132 | RFP (Ex530/40, Em605/55) | 1 unit |
| I10133 | mCherry (Ex580/25, Em645/75) | 1 unit |
| I10134 | ECFP (Ex436/20, Em480/40) | 1 unit |
| I10135 | EYFP (Ex500/20, Em535/30) | 1 unit |
| I10136 | DSRed (Ex530/40, Em620/60) | 1 unit |
| I10137 | Cy5 (Ex620/60, Em700/75) | 1 unit |
| I10138 | Cy7 (Ex710/75, Em810/90) | 1 unit |
| I10139 | Cy3/TRITC Long Pass (Ex530/40, Em570lp) | 1 unit |
| I10140 | GFP Long Pass (Ex470/40, Em500lp) | 1 unit |
| I10141 | Cy5 Long Pass (Ex620/60, Em665lp) | 1 unit |
| I10142 | Custom Filters | 1 unit |
| I10410 | Joystick | 1 unit |
| Supported labware | Slides, multi-well plates (6 to 1536 wells), petri dishes, culture flasks |
| Imaging modes | 4-channel fluorescence, brightfield, phase contrast, color brightfield |
| Light source | High-power LED filter cubes with adjustable intensity (>50,000 hours per filter cube) |
| Filter cube stage | Motorized; 4 interchangeable fluorescence filter cubes and 1 brightfield filter cube |
| Available filters | DAPI, EGFP, RFP, mCherry, ECFP, EYFP, DSRed, Cy5, Cy7, Cy3/TRITC Long Pass, GFP Long Pass, Cy5 Long Pass, custom filters |
| Objective turret | Motorized; 5 interchangeable objectives |
| Compatible objectives | 1.25-100X; Olympus, Zeiss, and Logos Biosystems objectives |
| Condenser | Motorized; basic or phase contrast Basic: 60 mm LWD condenser, 4 positions Phase contrast: 60 mm LWD condenser, 4 positions with 3 phase annuli |
| Camera | Monochrome: CMOS, 1.92 MP (optional) Color: CMOS, 1.92 MP |
| Image outputs | Monochrome: 16‐bit (12‐bit dynamic range) TIF, PNG, or JPG Color: 24-bit color TIF, PNG, or JPG Movies: MP4 |
| Autofocus method | Image-based autofocus (optional) Laser autofocus |
| Stage | Motorized X/Y-stage (120 mm x 80 mm); motorized Z-stage (10 mm) |
| Stage control | CELENA® X Explorer (optional) Joystick |
| Computer | External PC |
| Monitor | 27” 4K UHD monitor |
| Software | User interface: CELENA® X Explorer Analysis: CELENA® X Cell Analyzer |
| Power | 100-240 VAC, 250 W, 50/60 Hz |
| Dimensions | Main body: 39 x 46 x 50 cm (15.4 x 18.1 x 19.7 in) Controller: 17 x 30 x 23 cm (6.7 x 11.8 x 9.1 in) |
| Weight | Main body: 33 kg (72.8 lbs) Controller: 7 kg (15.4 lbs) |
