• Tissue Clearing

    X-CLARITY™ Systems & Reagents for Tissue Clearing

    The X-CLARITY™ is a collection of systems and ready-to-use reagents developed by Logos Biosystems to make electrophoretic tissue clearing simple, rapid, and efficient.

TISSUE CLEARING FOR 3D IMAGING

  • 01TISSUE-HYDROGEL HYBRIDIZATION
    Tissue clearing for 3d imaging X-CLARITY Hydrogel Solution Kit
    X-CLARITY™
    Hydrogel Solution Kit
    C1310X
    Tissue clearing for 3d imaging X-CLARITY Polymerization System
    X-CLARITY™
    Polymerization System
    C20001
  • 02TISSUE CLEARING
    Tissue clearing for 3d imaging X-CLARITY Tissue Clearing System II
    X-CLARITY™
    Tissue Clearing System II
    C30001
    Tissue clearing for 3d imaging Electrophoretic Tissue Clearing Solution
    Electrophoretic
    Tissue Clearing Solution
    C13001
  • 03ANTIBODY LABELING COMING SOON!
    Tissue clearing for 3d imaging DeepLabel Antibody Staining Kit
    DeepLabel™
    Antibody Staining Kit
    C33001
  • 04IMAGING
    Tissue clearing for 3d imaging X-CLARITY Mounting Solution
    X-CLARITY™
    Mounting Solution
    C13101
01

TISSUE-HYDROGEL HYBRIDIZATION

A fixed tissue sample is incubated in the X-CLARITY™ Hydrogel Solution Kit to allow hydrogel monomers to diffuse uniformly throughout the sample. Once the solution has permeated the tissue, the sample is placed in the X-CLARITY™ Polymerization System. Monomers polymerize in the anaerobic environment, covalently linking the biomolecules to a sturdy hydrogel network, preserving molecular information and structural integrity.
  • X-CLARITY™ Polymerization System C20001
    The X-CLARITY™ Polymerization System is a standalone, automated system developed to simplify tissue-hydrogel hybridization, a crucial step for optimal tissue clearing. Multiple samples can be placed in multi-well plates or conical tubes for rapid and efficient high-throughput sample processing. Users can control polymerization by adjusting vacuum strength, temperature, and a timer through a simple touchscreen interface. A ready-to-use X-CLARITY™ Hydrogel Solution Kit simplifies the process even further.
    App Note
  • Tissue-hydrogel hybridization X-CLARITY Polymerization System
  • LogosBiosystems X-CLARITY Polymerization System High throughput
    High throughput
    (up to 768 samples/run)
  • LogosBiosystems X-CLARITY Polymerization System Compatible with various vessels
    Compatible with various
    vessels
  • LogosBiosystems X-CLARITY Polymerization System Steady vacuum & temperature control
    Steady vacuum &
    temperature control
  • X-CLARITY Polymerization System Rapid and consistent polymerization
    Rapid and consistent
    polymerization
HYDROGEL SOLUTION KIT
    Cat # Product Qty MSDS Product Insert
    Request CoA   >
    02

    TISSUE CLEARING

    • X-CLARITY™ Tissue Clearing System II C30001
      The X-CLARITY™ Tissue Clearing System II is an all-in-one, easy-to-use solution for electrophoretic tissue clearing. Its unique design accelerates the removal of lipids from tissues while preserving the structural integrity of the sample. Clear a whole mouse brain in just 6 hours, an astounding 8 times faster than the original technology. Electrophoretic Tissue Clearing Solution is a premixed SDS-based buffer optimized for use with the system. This advanced system ensures that tissue clearing occurs efficiently and rapidly.
      APP NOTE Image Gallery
    • X-CLARITY Tissue Clearing System II
    • Precise temperature control
      • X-CLARITY Tissue Clearing System II Precise temperature control Active buffer cooling and heating capacity
        Active buffer cooling and
        heating capacity
      • X-CLARITY Tissue Clearing System II Precise temperature control Sensitive and accurate temperature sensor
        Sensitive and accurate
        temperature sensor
    • Uniform electric field
      • X-CLARITY Tissue Clearing System II Uniform electric field Platinum plated electrodes
        Platinum plated electrodes
      • X-CLARITY Tissue Clearing System II Uniform electric field Constant current and constant voltage modes
        Constant current and
        constant voltage modes
    • Compatible with multiple tissue types and sizes
      • X-CLARITY Tissue Clearing System II Compatible with multiple tissue types and sizes Active and passive clearing modes
        Active and passive clearing
        modes
      • Tissue Clearing System II Compatible with multiple tissue types and sizes Holders of various sizes available
        Holders of various sizes
        available
    • User-friendly setup
      • X-CLARITY Tissue Clearing System II User-friendly setup Simple touchscreen interface
        Simple touchscreen
        interface
      • X-CLARITY Tissue Clearing System II User-friendly setup Ready-to- use clearing solution
        Ready-to- use clearing
        solution
    ELECTROPHORETIC TISSUE CLEARING SOLUTION
      Cat # Product Qty MSDS Product Insert
      Request CoA   >
      03

      ANTIBODY LABELING

      • COMING SOON!
        DeepLabel™ Antibody Staining Kit
        C33001
        The DeepLabel™ Antibody Staining Kit enhances antibody penetration into large clarified tissues for vibrant fluorescence 3D imaging. DeepLabel facilitates the diffusion of molecular probes deep into thick, protein-dense tissues for robust and efficient antibody labeling. DeepLabel has been optimized for the antibody labeling of clarified tissues.
        • Efficient antibody penetration
        • Site-specific labeling
        • Deep permeation into thick tissues
        • Simple protocol with ready-to-use reagents
        • Vibrant imaging at subcellular resolution
      • Antibody labeling DeepLabel Antibody Staining Kit
      • DeepLabel enhances anti-Collagen Ⅳ penetration into clarified mouse brain tissues

        DeepLabel™ enhances anti-Collagen Ⅳ penetration into clarified mouse brain tissues.

      • DeepLabel Adult mouse brain stained using DeepLabel with anti-β-Amyloid, anti-Iba1, and anti-SMA

        Adult mouse brain stained using DeepLabel with anti-β-Amyloid (yellow), anti-Iba1 (red), and anti-SMA (purple).

      • Whole adult mouse brain stained using DeepLabel with anti-TH

        Whole adult mouse brain stained using DeepLabel with anti-TH (red).

      • Whole adult Drosophila brain stained using DeepLabel with anti-GFP and anti-TH

        Whole adult Drosophila brain stained using DeepLabel with anti-GFP (green) and anti-TH (red).

      04

      IMAGING

      • X-CLARITY™ Mounting Solution C13101 C13102 C13107
        X-CLARITY™ Mounting Solution is a high quality, cost-efficient refractive index matching solution (RIMS) modified from the recipe developed by Yang et al. The refractive index (RI) of the solution is 1.460 at 25°C and is stable over a wide temperature range. The X-CLARITY™ Mounting Solution minimizes photobleaching and preserves fluorescence signals, making it an ideal solution for clarified and labeled tissue samples.
        •   ·  RI = 1.460 at 25°C
        •   ·  Minimizes photobleaching
        •   ·  Preserves fluorescence signals
        App Note
      • Imaging X-CLARITY Mounting Solution
      Human cerebral cortex (1 mm)
      • X-CLARITY Mounting Solution Human cerebral cortex (1 mm) Before ETC PFA-fixed Seoul National University College of Medicine Hyung Jin Choi
        Before ETC
        PFA-fixed (1 week)
      • X-CLARITY Mounting Solution Human cerebral cortex (1 mm) After ETCSeoul National University College of Medicine Hyung Jin Choi
        After ETC
      • LogosBiosystems X-CLARITY Mounting Solution Human cerebral cortex (1 mm) After RI matching Seoul National University College of Medicine Hyung Jin Choi
        After RI matching
      Courtesy of Hyung Jin Choi, PhD
      Seoul National University College of Medicine
      Volumetric images of auditory neurons in a zebra finch brain (3 mm)
      • Volumetric images of auditory neurons in zebra finch brain slices cleared with the X-CLARITY and RI-matched with X-CLARITY Mounting Solution - PI & GFP
      • Volumetric images of auditory neurons in zebra finch brain slices cleared with the X-CLARITY and RI-matched with X-CLARITY Mounting Solution - GFP 500 um
      • Volumetric images of auditory neurons in zebra finch brain slices cleared with the X-CLARITY and RI-matched with X-CLARITY Mounting Solution - GFP 50 um
      Volumetric images of auditory neurons in zebra finch brain slices cleared with the X-CLARITY and RI-matched with X-CLARITY Mounting Solution. Auditory neurons of a zebra finch were labeled with GFP bilaterally via injection of a viral vector encoding GFP, stained with propidium iodide (PI) to visualize sample structure, and imaged with a light sheet microscope.
      Courtesy of Makoto Araki, PhD and Yuichi Morohashi, PhD
      Okinawa Institute of Science and Technology
      MOUNTING SOLUTION
        Cat # Product Qty MSDS Product Insert
        Request CoA   >
        BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples D Hörl, FR Rusak, F Preusser, P Tillberg, N Rande, RK Chhetri, A Cardona, PJ Keller, H Harz, H Leonhardt, M Treier, S Preibisch bioRxiv 343954 (2018) SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C Nature Communications 9, 2192 (2018) PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ Scientific Reports 8, 7182 (2018) Subepithelial telocytes are an important source of Wnts that supports intestinal crypts Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH Nature 557, 242–246 (2018) Heart clearing opens new insights in the quantification of injured area after ischemia reperfusion Paccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C Archives of Cardiovascular Diseases Supplements 10(2), 254 (2018) Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion Asboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G. Nature Neuroscience 21, 576-588 (2018) 3D imaging in the postmortem human brain with CLARITY and CUBIC Ando K, Laborde Q, Brion JP, Duyckaerts C Handbook of Clinical Neurology 150, 303-317 Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y Nature Communications 9, 559 (2018) Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids Lee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ RSC Advances 8, 4494-4502 (2018) Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome Lamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia, LJ eLife 7: e31150 (2018) Rapid spheroid clearing on a microfluidic chip Santisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M Lab on a Chip 18, 153-161 (2018) Optical clearing for multi‐scale biological tissues Yu T, Qi Y, Gong H, Luo Q, Zhu D Journal of Biophotonics 11(2), e201700187 (2018) Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N Cell 171, 398-413 (2017) Effects of neural stem cell media on hypoxic injury in rat hippocampal slice cultures Lee NM, Chae SA, Lee HJ Brain Research 1677, 20-25 (2017) Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility Johnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F Progress in Biophysics & Molecular Biology 130, 140-149 (2017) Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL Nature Communications 8, 367 (2017) Advances and perspectives in tissue clearing using CLARITY Jensen KHR, Berg RW Journal of Chemical Neuroanatomy 86, 19-34 (2017) Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens Glaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC Nature Biomedical Engineering 1, 0084 (2017) Graphene Oxide-Quenching-Based Fluorescence In Situ Hybridization (G-FISH) To Detect RNA In Tissue: Simple And Fast Tissue RNA Diagnostics Hwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS bioRxiv 143628 (2017) ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W Scientific Reports 6, 618631 (2016)
        DeepLabel™ Antibody Staining Kit Flyer X-CLARITY™ Brochure X-CLARITY™ Flyer C10001 X-CLARITY™ Tissue Clearing System Quick Start Guide C30001 X-CLARITY™ Tissue Clearing System II Installation Guide Preserving endogenous fluorescent protein signals for volumetric imaging using the X-CLARITY™ systems and reagents for tissue clearing ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging The X-CLARITY™ Mounting Solution: an improved RI matching solution for tissues cleared by the X-CLARITY™ Tissue Clearing System An automated and high-throughput polymerization solution for downstream tissue clearing: the X-CLARITY™ Polymerization System Logos Biosystems Products Brochure X-CLARITY Tissue Clearing System II S/W ver 1.1.0 X-CLARITY Polymerization S/W ver 1.1.0

        WHAT DO OUR CUSTOMERS HAVE TO SAY?

        Testimonials
        • Doug Richardson, PhD

          Harvard Center for Biological Imaging

          Logos Biosystems Harvard Center for Biological Imaging Doug Richardson X-CLARITY Tissue Clearing System

          We purchased the X-CLARITY Tissue Clearing System for our facility and have been very satisfied with its easy-to-use design and consistent results. The X-CLARITY Tissue Clearing System has now allowed many more researchers to enter the field of tissue clearing. In my opinion, the X-CLARITY Tissue Clearing System along with the recently introduced X-CLARITY Polymerization System will help expand the availability of this technique to all scientists who hope to add it to their laboratory’s repertoire.

        • Uri Manor, PhD

          Salk Institute for Biological Studies

          The X-CLARITY system is a delight to use and significantly lowers the barrier to tissue clearing imaging applications. With better clearing, and faster turnaround time, we were able to generate many more samples and images than would otherwise have been possible. Highly recommended!

        • Yoko Yazaki-Sugiyama, PhD

          Okinawa Institute of Science and Technology

          For quite a while we were using passive immersion method to obtain transparent zebra finch brains, but this was time-consuming and always a pain in the neck. With the X-CLARITY Tissue Clearing System, even a whole brain can be cleared within several hours with excellent consistency as well as better signal-to-noise ratio when acquiring fluorescent images from deep tissue. It has made our lives a lot easier. TIME IS MONEY!

        • Robert Hunt, PhD

          University of California, Irvine

          We were not sure what to expect when we tried the X-CLARITY Tissue Clearing System. I've tried other tissue clearing methods with varying levels of success. When Jan, a first-year graduate student, showed me a fully cleared whole mouse brain on his first try, I was really impressed! I think this system will really speed up his work.

        • Annick Prigent & Benoît Delatour, PhD

          ICM Histomics

          Logos Biosystems ICM Histomics Annick Prigent & Benoît Delatour X-CLARITY Tissue Clearing System

          The X-CLARITY allows us to perform rapid, efficient, and standardized clearing of mouse and human brain tissues. Access to the X-CLARITY technology will undoubtedly help the ICM research teams to better understand the 3D organization of protein assemblies and organelles in tissues.

        • Woong Sun, PhD

          Korea University Medical School

          Logos Biosystems Korea University Medical School Woong Sun X-CLARITY Tissue Clearing System

          I tried to design my own DIY ETC chamber for a long time without any success. I tried the X-CLARITY Tissue Clearing System and got a transparent mouse brain on my first try. It works really well and is easy to use. I’ve successfully imaged tissues that contain GFP or that I’ve labeled with fluorescence-tagged antibodies. It makes tissue clearing a stress free process.

        • Youngshik Choe, PhD

          Korea Brain Research Institute

          Logos Biosystems Korea Brain Research Institute Youngshik Choe X-CLARITY Tissue Clearing System

          I find the X-CLARITY simplifies the CLARITY procedure and gives consistent transparency of tissues by plug and play steps.
          The best of it is the speed that can't be achieved by other methods.

        • Yun Kyoung Kang, PhD

          Baylor College of Medicine

          I have tried various tissues besides the brain with the X-CLARITY Tissue Clearing System from Logos Biosystems. The X-CLARITY™ makes CLARITY simple and easy to apply. The X-CLARITY™ produces consistent clearing results with any tissue, including tumors, within a couple of days rather than weeks. Very impressive!

        + SHOW OUR CUSTOMERS

        WHERE THE X-CLARITY™ HAS BEEN CITED

        Citations
        • BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples
          D Hörl, FR Rusak, F Preusser, P Tillberg, N Rande, RK Chhetri, A Cardona, PJ Keller, H Harz, H Leonhardt, M Treier, S Preibisch
          bioRxiv 343954 (2018)

        • SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
          Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C
          Nature Communications 9, 2192 (2018)

        • PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types
          Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ
          Scientific Reports 8, 7182 (2018)

        • Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
          Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH
          Nature 557, 242–246 (2018)

        • Heart clearing opens new insights in the quantification of injured area after ischemia reperfusion
          Paccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C
          Archives of Cardiovascular Diseases Supplements 10(2), 254 (2018)

        • Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
          Asboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G.
          Nature Neuroscience 21, 576-588 (2018)

        • 3D imaging in the postmortem human brain with CLARITY and CUBIC
          Ando K, Laborde Q, Brion JP, Duyckaerts C
          Handbook of Clinical Neurology 150, 303-317

        • Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
          Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y
          Nature Communications 9, 559 (2018)

        • Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids
          Lee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ
          RSC Advances 8, 4494-4502 (2018)

        • Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome
          Lamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia, LJ
          eLife 7: e31150 (2018)

        • Rapid spheroid clearing on a microfluidic chip
          Santisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M
          Lab on a Chip 18, 153-161 (2018)

        • Optical clearing for multi‐scale biological tissues
          Yu T, Qi Y, Gong H, Luo Q, Zhu D
          Journal of Biophotonics 11(2), e201700187 (2018)

        • Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues
          Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N
          Cell 171, 398-413 (2017)

        • Effects of neural stem cell media on hypoxic injury in rat hippocampal slice cultures
          Lee NM, Chae SA, Lee HJ
          Brain Research 1677, 20-25 (2017)

        • Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility
          Johnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F
          Progress in Biophysics & Molecular Biology 130, 140-149 (2017)

        • Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis
          Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL
          Nature Communications 8, 367 (2017)

        • Advances and perspectives in tissue clearing using CLARITY
          Jensen KHR, Berg RW
          Journal of Chemical Neuroanatomy 86, 19-34 (2017)

        • Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens
          Glaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC
          Nature Biomedical Engineering 1, 0084 (2017)

        • Graphene Oxide-Quenching-Based Fluorescence In Situ Hybridization (G-FISH) To Detect RNA In Tissue: Simple And Fast Tissue RNA Diagnostics
          Hwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS
          bioRxiv 143628 (2017)

        • ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging
          Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W
          Scientific Reports 6, 618631 (2016)

        SHOW MORE  +

        Resources

        Downloads
          Videos

          Single-neuron segmentation of 3D confocal images of clarified tissues

          DataBrain: Using deep imaging techniques to develop a high-fidelity map of the brain

          Multiscale analysis of ischemia-reperfusion syndrome

          Studying molecular mechanisms of ischemia-reperfusion

          Polymerization simplified

          The new X-CLARITY™ sample holders

          Innovations in Spinal Treatment using Electrophoretic Tissue Clearing

          Spinal Treatment Techniques in the Lab

          How the CLARITY Method Supports Spinal Cord Research

          A journey through the brain

          Whole mouse brain cleared

          Biocompare explains CLARITY

          Mouse brain slice cleared

          Accessories
            • X-CLARITY™ Heat Block for 6 x 50 mL tubes

              Catalog #: C20002
              Quantity : 1 unit
              Holds six 50 mL conical tube

            • X-CLARITY™ Heat Block for flat-bottom plates

              Catalog #: C20003
              Quantity : 1 unit
              Holds one flat-bottom plate

            • Tissue Container

              Catalog #: C12001
              Quantity : 20 units
              Holds one adult mouse brain

            • Mouse Brain Slice Holder

              Catalog #: C12004
              Quantity : 1 unit
              Holds up to three mouse brain slices

            • Container Holder for 1 Tissue Container

              Catalog #: C12002
              Quantity : 1 unit
              Holds one tissue container

            • Whole Rat Brain Holder

              Catalog #: C12007
              Quantity : 1 unit
              Holds one adult rat brain or two adult mouse brains

            • Holder for 36 Mouse Brain Slices

              Catalog #: C12010 - 1.5 Φ
              Catalog #: C12020 - 0.6 Φ

              · 7 1.5 Φ or 0.6 Φ Mesh Plates
              · 6 Spacers for 6 Slices
              · 3 silicone rings

              Well size: 16.8 x 16.8 x 2 mm
              Sample: 36 mouse brain slices

            • Holder for 6 Slices

              Catalog #: C12011 - 1.5 Φ
              Catalog #: C12021 - 0.6 Φ

              · 7 1.5 Φ or 0.6 Φ Mesh Plates
              · 6 Spacers for 1 Slice
              · 3 silicone rings

              Well size: 35 x 53 x 2 mm
              Sample: 6 slices

            • Holder for 1 Sample

              Catalog #: C12012 - 1.5 Φ
              Catalog #: C12022 - 0.6 Φ

              · 7 1.5 Φ or 0.6 Φ Mesh Plates
              · 6 Spacers for 6 Slices
              · 3 silicone rings

              Well size: 35 x 53 x 20 mm
              Sample: 1 sample

            • Holder for 6 Mouse Brains

              Catalog #: C12013 - 1.5 Φ
              Catalog #: C12023 - 0.6 Φ

              · 2 1.5 Φ or 0.6 Φ Mesh Plates
              · 1 Spacer for 6 Mouse Brains
              · 3 silicone rings

              Well size: 16.8 x 16.8 x 20 mm
              Sample: 6 adult mouse brains

            • Holder for 48 Samples

              Catalog #: C12014 - 1.5 Φ
              Catalog #: C12024 - 0.6 Φ

              · 3 1.5 Φ or 0.6 Φ Mesh Plates
              · 2 Spacers for 24 Samples
              · 3 silicone rings

              Well size: 6.5 x 6.5 x 10 mm
              Sample: 48 samples

            • Holder for 192 Samples

              Catalog #: C12015 - 1.5 Φ
              Catalog #: C12025 - 0.6 Φ

              · 3 1.5 Φ or 0.6 Φ Mesh Plates
              · 2 Spacers for 96 Samples
              · 3 silicone rings

              Well size: 3 x 3 x 10 mm
              Sample: 192 samples

          show more  +

          ORDERING INFORMATION

          Cat # Product Qty
          C20001 X-CLARITY™ Polymerization System 1 unit
          C20002 X-CLARITY™ Heat Block for 6 x 50 mL tubes 1 unit
          C20003 X-CLARITY™ Heat Block for flat-bottom plates 1 unit
          C1310X X-CLARITY™ Hydrogel Solution Kit 1 kit
          C30001 X-CLARITY™ Tissue Clearing System II 1 unit
          C12010 Holder for 36 Mouse Brain Slices (1.5 Φ) 1 set
          C12020 Holder for 36 Mouse Brain Slices (0.6 Φ) 1 set
          C12011 Holder for 6 Slices (1.5 Φ) 1 set
          C12021 Holder for 6 Slices (0.6 Φ) 1 set
          C12012 Holder for 1 Sample (1.5 Φ) 1 set
          C12022 Holder for 1 Sample (0.6 Φ) 1 set
          C12013 Holder for 6 Mouse Brains (1.5 Φ) 1 set
          C12023 Holder for 6 Mouse Brains (0.6 Φ) 1 set
          C12014 Holder for 48 Samples (1.5 Φ) 1 set
          C12024 Holder for 48 Samples (0.6 Φ) 1 set
          C12015 Holder for 192 Samples (1.5 Φ) 1 set
          C12025 Holder for 192 Samples (0.6 Φ) 1 set
          C12001 Tissue Container (20 units) 1 box
          C12002 Container Holder for 1 Tissue Container 1 unit
          C12004 Mouse Brain Slice Holder 1 unit
          C12007 Whole Rat Brain Holder 1 unit
          C13001 Electrophoretic Tissue Clearing Solution 12 x 1 L
          C13101 X-CLARITY™ Mounting Solution 1 x 25 mL
          C13102 X-CLARITY™ Mounting Solution Value Pack 10 x 25 mL
          C13107 X-CLARITY™ Mounting Solution Bulk Pack 20 x 25 mL