• DOCUMENTS

    • Poster

      Icon The effects of DeepLabel Antibody Staining Kit on antibody penetration in diverse organs after tissue clearing with the X-CLARITY
      1.25 MB
    • Brochure

      Icon DeepLabel™ Antibody Staining Kit Flyer VDL1810-01
      458.10 KB
    • Brochure

      Icon X-CLARITY™ VX1901-01
      962KB
    • Brochure

      Icon X-CLARITY™ Flyer VX1810-01
      553 KB
    • Quick Start Guide

      Icon C10001 X-CLARITY™ Tissue Clearing System Quick Start Guide
      668.54 KB
    • Installation Guide

      Icon C30001 X-CLARITY™ Tissue Clearing System II Installation Guide
      841.04 KB
    • Brochure

      Icon Logos Biosystems Products
      2.14 MB
    • Product literature

      Icon Preserving endogenous fluorescent protein signals for volumetric imaging using the X-CLARITY™ systems and reagents for tissue clearing
      1.6 MB
    X-CLARITY™ Citations
    • Presynaptic boutons that contain mitochondria are more stable.
      2019. Lees RM, Johnson JD, Ashby MC. bioRxiv 580530.

    • A HaloTag-TEV genetic cassette for mechanical phenotyping of native proteins.
      2019. Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Linke WA, Fernández JM, Alegre-Cebollada J. bioRxiv 577445.

    • Development of sample-adaptable holders for lightsheet microscopy.
      2019. Laroche T, Burri O, Dubey LK, Seitz A. Frontiers in Neuroanatomy 13:26.

    • A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles.
      2019. Neckles VN, Morton MC, Holmberg JC, Sokolov AM, Nottoli T, Liu D, Feliciano DM. Scientific Reports 9(1): 3094.

    • A novel optical tissue clearing protocol for mouse skeletal muscle to visualize endplates in their tissue context.
      2019. Williams MPI, Rigon M, Straka T, Hörner SJ, Thiel M, Gretz N, Hafner M, Reischl M, Rudolf R. Frontiers in Cellular Neuroscience 13: 49.

    • Bioinspired neuron-like electronics.
      2019. Yang X, Zhou T, Zwang TJ, Hong G, Zhao Y, Viveros RD, Fu TM, Gao T, Lieber CM. Nature Materials.

    • A novel population of long-range inhibitory neurons.
      2019. Wick ZC, Tetzlaff MR, Krook-Magnuson E. bioRxiv 554360.

    • Expansion light sheet microscopy resolves subcellular structures in large portions of the songbird brain.
      2019. Düring DN, Rocha MD, Dittrich F, Gahr M, Hahnloser RHR. Frontiers in Neuroanatomy 13:2.

    • Graphene oxide-quenching-based fluorescence in situ hybridization (G-FISH) to detect RNA in tissue: Simple and fast tissue RNA diagnostics.
      2018. Hwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS. Nanomedicine 16, 162-172.

    • Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
      2018. De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. Brain Pathology.

    • Specimen preparation.
      2018. Jerome WG, Fuseler J, Padgett CA, Price RL. ). Basic Confocal Microscopy, 73–97.

    • Combined structural and functional imaging of the kidney reveals major axial differences in proximal tubule endocytosis.
      2018. Schuh CD, Polesel M, Platonova E, Haenni D, Gassama A, Tokonami N, Ghazi S, Bugarski M, Devuyst O, Ziegler U, Hall AM. Journal of the American Society of Nephrology, 29(11): 2696-2712.

    • Combined structural and functional imaging of the kidney reveals major axial differences in proximal tubule endocytosis.
      2018. Schuh CD, Polesel M, Platonova E, Haenni D, Gassama A, Tokonami N, Ghazi S, Bugarski M, Devuyst O, Ziegler U, Hall AM. Journal of the American Society of Nephrology 29(11), 2696-2712.

    • Optical tissue clearing in combination with perfusion and immunofluorescence for placental vascular imaging.
      2018. Carrillo M, Chuecos M, Gandhi K, Bednov A, Moore DL, Maher J, Ventolini G, Ji G, Schlabritz-Loutsevitch N. Medicine (Baltimore) 97(39), e12392.

    • The neuroregenerative capacity of olfactory stem cells is not limitless: Implications for aging.
      2018. Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. Journal of Neuroscience 38(31), 6806-6824.

    • BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples.
      2018. Hörl D, Rusak FR, Preusser F, Tillberg P, Rande N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M, Preibisch S. bioRxiv 343954.

    • SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.
      2018. Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C. Nature Communications 9, 2192.

    • PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types.
      2018. Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ. Scientific Reports 8, 7182.

    • Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.
      2018. Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH. Nature 557, 242–246.

    • Latrophilin 2 specifies cardiac lineage commitment and heart development.
      2018. Lee CS, Cho HJ, Lee JW, Lee J, Kwon YW, Park H, Kim J, Kim HS. SSRN Electronic Journal.

    • Heart clearing opens new insights in the quantification of injured area after ischemia reperfusion.
      2018. Paccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C. Archives of Cardiovascular Diseases Supplements 10(2), 254.

    • Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
      2018. Asboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G. Nature Neuroscience 21, 576-588.

    • 3D imaging in the postmortem human brain with CLARITY and CUBIC.
      2018. Ando K, Laborde Q, Brion JP, Duyckaerts C. Handbook of Clinical Neurology 150, 303-317.

    • Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.
      2018. Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y. Nature Communications 9, 559.

    • Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids.
      2018. Lee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ. RSC Advances 8, 4494-4502.

    • Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome.
      2018. Lamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia LJ. eLife 7: e31150.

    • Rapid spheroid clearing on a microfluidic chip.
      2018. Santisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M. Lab on a Chip 18, 153-161.

    • Optical clearing for multi‐scale biological tissues.
      2018. Yu T, Qi Y, Gong H, Luo Q, Zhu D. Journal of Biophotonics 11(2), e201700187.

    • Organism-level analysis of vaccination reveals networks of protection across tissues.
      2017. Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N. Cell 171, 398-413.

    • Effects of neural stem cell media on hypoxic injury in rat hippocampal slice cultures.
      2017. Lee NM, Chae SA, Lee HJ. Brain Research 1677, 20-25.

    • Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility.
      2017. Johnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F. Progress in Biophysics & Molecular Biology 130, 140-149.

    • Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.
      2017. Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL. Nature Communications 8, 367.

    • Advances and perspectives in tissue clearing using CLARITY.
      2017. Jensen KHR, Berg RW, Journal of Chemical Neuroanatomy 86, 19-34.

    • Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens.
      2017. Glaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC. Nature Biomedical Engineering 1, 0084.

    • ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging.
      2016. Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W. Scientific Reports 6, 618631.

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