• Flyer

      Icon DeepLabel™ Antibody Staining Kit
      458.10 KB
    • Brochure

      Icon X-CLARITY™ Systems and Reagents for Tissue Clearing
    • Brochure

      Icon Logos Biosystems Products
      2.14 MB
    • Poster

      Icon The effects of DeepLabel Antibody Staining Kit on antibody penetration in diverse organs after tissue clearing with the X-CLARITY
      1.25 MB
    • Flyer

      Icon X-CLARITY™ Systems and Reagents for Tissue Clearing
      553 KB
    • Quick Start Guide

      Icon X-CLARITY™ Tissue Clearing System
      668.54 KB
    • Installation Guide

      Icon X-CLARITY™ Tissue Clearing System II
      841.04 KB
    • Product literature

      Icon ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging
      2.6 MB
    X-CLARITY™ Citations
    • Influenza causes alterations to oligodendrocyte-specific transcripts and the myelin lipidome in the adult mouse central nervous system.
      2021. Louie A, Kim J, Soto-Diaz K, Dibaeinia P, Koito H, Sinha S, Nowak R, Das A, Steelman A. Research Squre https://doi.org/10.21203/rs.3.rs-310861/v1.

    • Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models.
      2021. Chourrout M, Rositi H, Ong E, Hubert V, Paccalet A, Foucault L, Autret A, Fayard B, Olivier C, Bolbos R, Peyrin F, Crola-da-Silva C, Meyronet D, Raineteau O, Elleaume H, Brun E, Chauveau F, Wiart M. bioRxiv 2021.03.24.436852.

    • Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels.
      2021. Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F. Cardiovascular Research cvab126.

    • 3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice.
      2020. Ded L, Hwang JY, Miki K, Shi HF, Chung JJ. Elife 9:e62043.

    • Maximizing lentiviral vector gene transfer in the CNS.
      2020. Humbel M, Ramosaj M, Zimmer V, Regio S, Aeby L, Moser S, Boizot A, Sipion M, Rey M, Déglon N. Gene Therapy 10.1038/s41434-020-0172-6.

    • Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii.
      2020. Boillat M, Hammoudi PM, Dogga SK, Pagès S, Goubran M, Rodriguez I, Soldati-Favre D. Cell Reports 30(2):320–334.e6.

    • Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.
      2020. Molina LM, Zhu J, Li Q, Sayed TPSK, Jenkins N, Vats R, Ko S, Hu S, Poddar M, Singh S, Tao J, Sundd P, Singhi A, Watkins S, Ma X, Benos PV, Feranchak A, Nejak-Bowen K, Watson A, Bell A, Monga SP. Biorxiv 2020.10.21.349159.

    • High resolution three-dimensional imaging of the ocular surface and intact eyeball using tissue clearing and light sheet microscopy.
      2020. Yang Y, Li G, Chen L. The Ocular Surface 18(3), 526–532.

    • Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.
      2020. Li Z, Hu B, Li G, Fox S, Jalal S, Turek J, Brown JQ, Nolte D. Journal of Biomedical Optics 25(9):096006.

    • Flow enhances phenotypic and maturation of adult rat liver organoids.
      2020. Jung DJ, Byeon JH, Jeong GS, Biofabrication 12(4):045035.

    • Antibody screening using a human iPSC‐based blood‐brain barrier model identifies antibodies that accumulate in the CNS.
      2020. Georgieva JV, Goulatis LI, Stutz CC, Canfield SG, Song HW, Gastfriend BD, Shusta EV. Official Publication of the Federation of American Societies for Experimental Biology 34(9):12549–12564.

    • CLARITY analysis of the Cl/pH sensor expression in the brain of transgenic mice.
      2020. Diuba AV, Samigullin DV, Kaszas A, Zonfrillo F, Malkov A, Petukhova E, Casini A, Arosio D, Esclapez M, Gross CT, Bregestovski P. Neuroscience 439:181-194.

    • A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues.
      2020. Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Fernández JM, Linke WA, Alegre-Cebollada J. Nature Communications 11(1):2060.

    • Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.
      2020. Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N. Alzheimer's & Dementia : The Journal of the Alzheimer's Association 16(5):734‐749.

    • Presynaptic Boutons That Contain Mitochondria Are More Stable
      2020. Lees RM, Johnson JD, Ashby MC. Frontiers in Synaptic Neuroscience 11:13

    • Transparent tumor microenvironment: Are liposomal nanoparticles sufficient for drug delivery to hypoxic regions and clonogenic cells?
      2020. Samson AAS, Hong S, Purushothaman B, Lee J, Song JM. Applied Materials Today V19 : 100561

    • β-Galactosylceramidase deficiency causes bone marrow vascular defects in an animal model of Krabbe disease
      2020. Belleri M, Coltrini D, Righi M, Ravelli C, Taranto S, Chiodelli P, Mitola S, Presta M, Giacomini A. International Journal of Molecular Sciences 21(1): 251.

    • Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis.
      2019. Lyons CE, Razzoli M, Larson E, Svedberg D, Frontini A, Cinti S, Vulchanova L, Sanders M, Thomas M, Bartolomucci A. The FASEB Journal 00: 1-9.

    • Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix.
      2019. Thierry M, Boluda S, Delatour B, Marty S, Seilhean D, Brainbank Neuro-CEB Neuropathology Network, Potier MC, Duyckaerts C. Acta Neuropathalogica: 1-19.

    • Orthopedic surgery triggers attention deficits in a delirium-like mouse model.
      2019. Velagapudi R, Subramaniyan S, Xiong C, Porkka F, Rodriguiz RM, Wetsel WC, Terrando N. Frontiers in Immunology 10: 2675.

    • Coronary revascularization during heart regeneration is regulated by epicardial and endocardial cues and forms a scaffold for cardiomyocyte repopulation.
      2019. Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR. Developmental Cell 51(4): 503-515.

    • Functional characterisation of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.
      2019. Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh JT, Winlaw D, Giannoulatou E, Chapman G, Dunwoodie SL. Human Molecular Genetics ddz231.

    • Imbalance in the response of pre- and post-synaptic components to amyloidopathy.
      2019. Stephen TL, Tamagnini F, Piegsa J, Sung K, Harvey J, Oliver-Evans A, Murray TK, Ahmed Z, Hutton ML, Randall A, O'Neill MJ, Jackson JS. Scientific Reports 9(1): 14837.

    • Novel long-range inhibitory nNOS-expressing hippocampal cells.
      2019. Wick ZC, Tetzlaff MR, Krook-Magnuson E. eLIFE 8: e46816.

    • Neuroprotective effect of nerve growth factor loaded in porous silicon nanostructures in an Alzheimer's disease model and potential delivery to the brain.
      2019. Zilony-Hanin N, Rosenberg M, Richman M, Yehuda R, Schori H, Motiei M,, Rahimipour S, Groisman A, Segal E, Shefi O. Small 15(45): e1904203.

    • Multiplex immunolabeling and imaging of functionally essential kidney structures in X-CLARITY-cleared tissue.
      2019. Mochama P, Tyshynsky R, Sanders MA. Microscopy and Microanalysis 25(Supplement S2): 1260-1261.

    • BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples.
      2019. Hörl D, Rusak FR, Preusser F, Tillberg P, Rande N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M, Preibisch S. Nature Methods 16: 870–874

    • Clarity analysis of the Cl/pH sensor expression in the brain of transgenic mice.
      2019. Diuba AV, Samigullin DV, Kaszas A, Zonfrillo F, Malkov A, Peukhova E, Casini A, Arosio D, Esclapez M, Gross CT, Bregestovski P. Neuroscience.

    • Enhanced resolution 3D digital cytology and pathology with dual-view inverted selective plane illumination microscopy.
      2019. Hu B, Li G, Brown JQ. Biomedical Optics Express 10(8): 3833-3846.

    • High-performance acellular tissue scaffold combined with hydrogel polymers for regenerative medicine.
      2019. Lee E, Kim HJ, Shaker MR, Ryu JR, Ham MS, Seo SH, Kim DH, Lee K, Jung N, Choe Y, Son GH, Ryu IJ, Kim H, Sun W. ACS Biomaterials Science & Engineering 5(7): 3462-3474.

    • Presynaptic boutons that contain mitochondria are more stable.
      2019. Lees RM, Johnson JD, Ashby MC. bioRxiv 580530.

    • A HaloTag-TEV genetic cassette for mechanical phenotyping of native proteins.
      2019. Rivas-Pardo JA, Li Y, Mártonfalvi Z, Tapia-Rojo R, Unger A, Fernández-Trasancos Á, Herrero-Galán E, Velázquez-Carreras D, Linke WA, Fernández JM, Alegre-Cebollada J. bioRxiv 577445.

    • Development of sample-adaptable holders for lightsheet microscopy.
      2019. Laroche T, Burri O, Dubey LK, Seitz A. Frontiers in Neuroanatomy 13:26.

    • A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles.
      2019. Neckles VN, Morton MC, Holmberg JC, Sokolov AM, Nottoli T, Liu D, Feliciano DM. Scientific Reports 9(1): 3094.

    • A novel optical tissue clearing protocol for mouse skeletal muscle to visualize endplates in their tissue context.
      2019. Williams MPI, Rigon M, Straka T, Hörner SJ, Thiel M, Gretz N, Hafner M, Reischl M, Rudolf R. Frontiers in Cellular Neuroscience 13: 49.

    • Bioinspired neuron-like electronics.
      2019. Yang X, Zhou T, Zwang TJ, Hong G, Zhao Y, Viveros RD, Fu TM, Gao T, Lieber CM. Nature Materials.

    • A novel population of long-range inhibitory neurons.
      2019. Wick ZC, Tetzlaff MR, Krook-Magnuson E. bioRxiv 554360.

    • Expansion light sheet microscopy resolves subcellular structures in large portions of the songbird brain.
      2019. Düring DN, Rocha MD, Dittrich F, Gahr M, Hahnloser RHR. Frontiers in Neuroanatomy 13:2.

    • Graphene oxide-quenching-based fluorescence in situ hybridization (G-FISH) to detect RNA in tissue: Simple and fast tissue RNA diagnostics.
      2018. Hwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS. Nanomedicine 16, 162-172.

    • Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
      2018. De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G. Brain Pathology.

    • Specimen preparation.
      2018. Jerome WG, Fuseler J, Padgett CA, Price RL. ). Basic Confocal Microscopy, 73–97.

    • Combined structural and functional imaging of the kidney reveals major axial differences in proximal tubule endocytosis.
      2018. Schuh CD, Polesel M, Platonova E, Haenni D, Gassama A, Tokonami N, Ghazi S, Bugarski M, Devuyst O, Ziegler U, Hall AM. Journal of the American Society of Nephrology, 29(11): 2696-2712.

    • Optical tissue clearing in combination with perfusion and immunofluorescence for placental vascular imaging.
      2018. Carrillo M, Chuecos M, Gandhi K, Bednov A, Moore DL, Maher J, Ventolini G, Ji G, Schlabritz-Loutsevitch N. Medicine (Baltimore) 97(39), e12392.

    • Optimizing tissue-clearing conditions based on analysis of the critical factors affecting tissue-clearing procedures.
      2018. Kim JH, Jang MJ, Choi J, Lee E, Song KD, Cho J, Kim KT, Cha HJ, Sun W. Scientific Reports, 8(1):12815.

    • The neuroregenerative capacity of olfactory stem cells is not limitless: Implications for aging.
      2018. Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. Journal of Neuroscience 38(31), 6806-6824.

    • SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.
      2018. Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C. Nature Communications 9, 2192.

    • PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types.
      2018. Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ. Scientific Reports 8, 7182.

    • Subepithelial telocytes are an important source of Wnts that supports intestinal crypts.
      2018. Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH. Nature 557, 242–246.

    • Latrophilin 2 specifies cardiac lineage commitment and heart development.
      2018. Lee CS, Cho HJ, Lee JW, Lee J, Kwon YW, Park H, Kim J, Kim HS. SSRN Electronic Journal.

    • Heart clearing opens new insights in the quantification of injured area after ischemia reperfusion.
      2018. Paccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C. Archives of Cardiovascular Diseases Supplements 10(2), 254.

    • Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
      2018. Asboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G. Nature Neuroscience 21, 576-588.

    • 3D imaging in the postmortem human brain with CLARITY and CUBIC.
      2018. Ando K, Laborde Q, Brion JP, Duyckaerts C. Handbook of Clinical Neurology 150, 303-317.

    • Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.
      2018. Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y. Nature Communications 9, 559.

    • Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids.
      2018. Lee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ. RSC Advances 8, 4494-4502.

    • Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome.
      2018. Lamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia LJ. eLife 7: e31150.

    • Rapid spheroid clearing on a microfluidic chip.
      2018. Santisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M. Lab on a Chip 18, 153-161.

    • Optical clearing for multi‐scale biological tissues.
      2018. Yu T, Qi Y, Gong H, Luo Q, Zhu D. Journal of Biophotonics 11(2), e201700187.

    • Organism-level analysis of vaccination reveals networks of protection across tissues.
      2017. Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N. Cell 171, 398-413.

    • Effects of neural stem cell media on hypoxic injury in rat hippocampal slice cultures.
      2017. Lee NM, Chae SA, Lee HJ. Brain Research 1677, 20-25.

    • Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility.
      2017. Johnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F. Progress in Biophysics & Molecular Biology 130, 140-149.

    • Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.
      2017. Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL. Nature Communications 8, 367.

    • Advances and perspectives in tissue clearing using CLARITY.
      2017. Jensen KHR, Berg RW, Journal of Chemical Neuroanatomy 86, 19-34.

    • Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens.
      2017. Glaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC. Nature Biomedical Engineering 1, 0084.

    • ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging.
      2016. Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W. Scientific Reports 6, 618631.

    show MORE   +