• DOCUMENTS

    • Poster

      Icon The effects of DeepLabel Antibody Staining Kit on antibody penetration in diverse organs after tissue clearing with the X-CLARITY
      1.25 MB
    • Brochure

      Icon DeepLabel™ Antibody Staining Kit Flyer VDL1810-01
      458.10 KB
    • Brochure

      Icon X-CLARITY™ VX1901-01
      962KB
    • Brochure

      Icon X-CLARITY™ Flyer VX1810-01
      553 KB
    • Quick Start Guide

      Icon C10001 X-CLARITY™ Tissue Clearing System Quick Start Guide
      668.54 KB
    • Installation Guide

      Icon C30001 X-CLARITY™ Tissue Clearing System II Installation Guide
      841.04 KB
    • Brochure

      Icon Logos Biosystems Products
      2.14 MB
    • Product literature

      Icon Preserving endogenous fluorescent protein signals for volumetric imaging using the X-CLARITY™ systems and reagents for tissue clearing
      1.6 MB
    X-CLARITY™ Citations
    • Graphene oxide-quenching-based fluorescence in situ hybridization (G-FISH) to detect RNA in tissue: Simple and fast tissue RNA diagnostics
      Hwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS
      Nanomedicine 16, 162-172 (2018)

    • Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models
      De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G
      Brain Pathology (2018)

    • Combined structural and functional imaging of the kidney reveals major axial differences in proximal tubule endocytosis
      Schuh CD, Polesel M, Platonova E, Haenni D, Gassama A, Tokonami N, Ghazi S, Bugarski M, Devuyst O, Ziegler U, Hall AM
      Journal of the American Society of Nephrology 29(11), 2696-2712 (2018)

    • Optical tissue clearing in combination with perfusion and immunofluorescence for placental vascular imaging
      Carrillo M, Chuecos M, Gandhi K, Bednov A, Moore DL, Maher J, Ventolini G, Ji G, Schlabritz-Loutsevitch N
      Medicine (Baltimore) 97(39), e12392 (2018)

    • The neuroregenerative capacity of olfactory stem cells is not limitless: Implications for aging
      Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W
      Journal of Neuroscience 38(31), 6806-6824 (2018)

    • BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples
      Hörl D, Rusak FR, Preusser F, Tillberg P, Rande N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M, Preibisch S
      bioRxiv 343954 (2018)

    • SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
      Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C
      Nature Communications 9, 2192 (2018)

    • PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types
      Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ
      Scientific Reports 8, 7182 (2018)

    • Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
      Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH
      Nature 557, 242–246 (2018)

    • Latrophilin 2 specifies cardiac lineage commitment and heart development
      Lee CS, Cho HJ, Lee JW, Lee J, Kwon YW, Park H, Kim J, Kim HS
      SSRN Electronic Journal (2018)

    • Heart clearing opens new insights in the quantification of injured area after ischemia reperfusion
      Paccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C
      Archives of Cardiovascular Diseases Supplements 10(2), 254 (2018)

    • Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
      Asboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G.
      Nature Neuroscience 21, 576-588 (2018)

    • 3D imaging in the postmortem human brain with CLARITY and CUBIC
      Ando K, Laborde Q, Brion JP, Duyckaerts C
      Handbook of Clinical Neurology 150, 303-317 (2018)

    • Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
      Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y
      Nature Communications 9, 559 (2018)

    • Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroids
      Lee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ
      RSC Advances 8, 4494-4502 (2018)

    • Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome
      Lamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia, LJ
      eLife 7: e31150 (2018)

    • Rapid spheroid clearing on a microfluidic chip
      Santisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M
      Lab on a Chip 18, 153-161 (2018)

    • Optical clearing for multi‐scale biological tissues
      Yu T, Qi Y, Gong H, Luo Q, Zhu D
      Journal of Biophotonics 11(2), e201700187 (2018)

    • Organism-level analysis of vaccination reveals networks of protection across tissues
      Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N
      Cell 171, 398-413 (2017)

    • Effects of neural stem cell media on hypoxic injury in rat hippocampal slice cultures
      Lee NM, Chae SA, Lee HJ
      Brain Research 1677, 20-25 (2017)

    • Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility
      Johnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F
      Progress in Biophysics & Molecular Biology 130, 140-149 (2017)

    • Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis
      Dubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL
      Nature Communications 8, 367 (2017)

    • Advances and perspectives in tissue clearing using CLARITY
      Jensen KHR, Berg RW
      Journal of Chemical Neuroanatomy 86, 19-34 (2017)

    • Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens
      Glaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC
      Nature Biomedical Engineering 1, 0084 (2017)

    • ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging
      Lee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W
      Scientific Reports 6, 618631 (2016)

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