• Brochure

      Icon X-CLARITY™
    • Brochure

      Icon X-CLARITY™ Flyer VX1606-01
      553 KB
    • Quick Start Guide

      Icon C10001 X-CLARITY™ Tissue Clearing System Quick Start Guide
      668.54 KB
    • Installation Guide

      Icon C30001 X-CLARITY™ Tissue Clearing System II Installation Guide
      841.04 KB
    • Product literature

      Icon Preserving endogenous fluorescent protein signals for volumetric imaging using the X-CLARITY™ systems and reagents for tissue clearing
      1.6 MB
    • Product literature

      Icon ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging
      2.6 MB
    • Product literature

      Icon The X-CLARITY™ Mounting Solution: an improved RI matching solution for tissues cleared by the X-CLARITY™ Tissue Clearing System
      1.5 MB
    • Product literature

      Icon An automated and high-throughput polymerization solution for downstream tissue clearing: the X-CLARITY™ Polymerization System
      1.4 MB
    X-CLARITY™ Citations
    • BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples
      D Hörl, FR Rusak, F Preusser, P Tillberg, N Rande, RK Chhetri, A Cardona, PJ Keller, H Harz, H Leonhardt, M Treier, S Preibisch
      bioRxiv 343954 (2018)

    • SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
      Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, Peronaci M, Lalowski M, Soliymani R, Mezzatesta C, Pirola A, Banfi F, Rubio A, Rea D, Stagno F, Usala E, Martino B, Campiotti L, Merli M, Passamonti F, Onida F, Morotti A, Pavesi F, Bregni M, Broccoli V, Baumann M, Gambacorti-Passerini C
      Nature Communications 9, 2192 (2018)

    • PrismPlus: a mouse line expressing distinct fluorophores in four different brain cell types
      Gaire J, Lee HC, Ward R, Currlin S, Woolley AJ, Coleman JE, Williams JC, Otto KJ
      Scientific Reports 8, 7182 (2018)

    • Subepithelial telocytes are an important source of Wnts that supports intestinal cryptsShoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH Nature 557, 242–246 (2018)

    • Heart clearing opens new insights in the quantification of injured area after ischemia reperfusionPaccalet A, Badawi S, Gouriou Y, Bidaux G, Crola Da Silva C
      Archives of Cardiovascular Diseases Supplements 10(2), 254 (2018)

    • Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusionAsboth L, Friedli L, Beauparlant J, Martinez-Gonzalez C, Anil S, Rey E, Baud L, Pidpruzhnykova G, Anderson MA, Shkorbatova P,, Batti L, Pagès S, Kreider J, Schneider BL, Barraud Q, Courtine G. Nature Neuroscience 21, 576-588 (2018)

    • 3D imaging in the postmortem human brain with CLARITY and CUBICAndo K, Laborde Q, Brion JP, Duyckaerts C Handbook of Clinical Neurology 150, 303-317

    • Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2αWang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y Nature Communications 9, 559 (2018)

    • Pitch-tunable pillar arrays for high-throughput culture and immunohistological analysis of tumor spheroidsLee DW, Kang J, Hwang HJ, Oh MS, Shin BC, Lee MY, Kuh HJ RSC Advances 8, 4494-4502 (2018)

    • Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcomeLamm KYB, Johnson ML, Phillips JB, Muntifering MB, James JM, Jones HN, Redline RW, Rokas A, Muglia, LJ eLife 7: e31150 (2018)

    • Rapid spheroid clearing on a microfluidic chipSantisteban TS, Rabajania O, Kalinina I, Robinson S, Meier M Lab on a Chip 18, 153-161 (2018)

    • Optical clearing for multi‐scale biological tissuesYu T, Qi Y, Gong H, Luo Q, Zhu D Journal of Biophotonics 11(2), e201700187 (2018)

    • Organism-Level Analysis of Vaccination Reveals Networks of Protection across TissuesKadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier N Cell 171, 398-413 (2017)

    • Effects of neural stem cell media on hypoxic injury in rat hippocampal slice culturesLee NM, Chae SA, Lee HJ Brain Research 1677, 20-25 (2017)

    • Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utilityJohnston CM, Rog-Zielinska, EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Shrneider-Warme F Progress in Biophysics & Molecular Biology 130, 140-149 (2017)

    • Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesisDubey LK, Karempudi P, Luther SA, Ludewig B, Harris NL Nature Communications 8, 367 (2017)

    • Advances and perspectives in tissue clearing using CLARITYJensen KHR, Berg RW Journal of Chemical Neuroanatomy 86, 19-34 (2017)

    • Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimensGlaser AK, Reder NP, Chen Y, McCarty EF, Yin C, Wei L, Wang Y, True LD, Liu JTC Nature Biomedical Engineering 1, 0084 (2017)

    • Graphene Oxide-Quenching-Based Fluorescence In Situ Hybridization (G-FISH) To Detect RNA In Tissue: Simple And Fast Tissue RNA DiagnosticsHwang DW, Choi YR, Kim D, Park HY, Kim KW, Kim MY, Park CK, Lee DS bioRxiv 143628 (2017)

    • ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imagingLee E, Choi J, Jo Y, Kim JY, Jang YJ, Lee HM, Kim SY, Lee HJ, Cho K, Jung N, Hur EM, Jeong SJ, Moon C, Choe Y, Rhyu IJ, Kim H, Sun W; Scientific Reports 6, 618631 (2016)

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